Structural Biology and Biocomputing Programme
نویسنده
چکیده
ɗ Reconstruct the structural details of protein complexes that are active in cell adhesion and metabolism. ɗ Predict the consequences of cancer related alterations ; we are focusing on alterations with a compensatory nature ( co-evolutionary related mutations ) as well as those affecting alternative splicing patterns. ɗ Contribute to the analysis of cancer epigenomic and genomic information within the framework of international genome projects.
منابع مشابه
Application of Knowledge Discovery to Molecular Biology: Identifying Structural Regularities in Proteins
In recent years, there has been an explosive amount of molecular biology information obtained and deposited in various databases. Identifying and interpreting interesting patterns from this massive amount of information has become an essential component in directing further molecular biology research. The goal of this research is to discover structural regularities in protein sequences by apply...
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Despite the advantages provided by the enormous recent increases in the availability of structural information, functional assignment for the large number of proteins represented in the sequence and structural genomics projects remains a pressing problem for genomic era biology. This section describes work relevant to this problem from several perspectives, including new approaches that take ad...
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Computer-based multimedia technology for distance learning and research has come of age--the price point is acceptable, domain experts using off-the-shelf software can prepare compelling materials, and the material can be efficiently delivered via the Internet to a large audience. While not presenting any new scientific results, this paper outlines experiences with a variety of commercial and f...
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There are various cases where the biological function of an RNA molecule involves a reversible change of conformation. paRNAss is a software approach to the prediction of such structural switching in RNA. It is based on three hypotheses about the secondary structure space of a switching RNA molecule, which can be evaluated by RNA folding and structure comparison. In the positive case, the predi...
متن کاملVector Quantization Kernels for the Classification of Protein Sequences and Structures
We propose a new kernel-based method for the classification of protein sequences and structures. We first represent each protein as a set of time series data using several structural, physicochemical, and predicted properties such as a sequence of consecutive dihedral angles, hydrophobicity indices, or predictions of disordered regions. A kernel function is then computed for pairs of proteins, ...
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تاریخ انتشار 2016